Oral Cancer: Spotting the Signs, Understanding the Causes, and Why Early Detection is Crucial

Oral cancer, also known as mouth cancer, is a serious condition that develops in the tissues of the oral cavity. This includes the lips, tongue, gums, inner cheeks, and the roof or floor of the mouth. In some instances, it can also affect the oropharynx, the area at the back of the throat. Often beginning as a painless sore or patch, it can easily go unnoticed in its early stages. Regular dental checkups and self-examinations are vital for early diagnosis. While it can affect anyone, certain lifestyle choices, such as tobacco and alcohol use, significantly elevate the risk. Early detection and prompt treatment are essential for improving outcomes and survival rates.

What is Oral Cancer?

Oral cancer is a type of head and neck cancer that originates in the tissues of the oral cavity, encompassing areas like the lips, tongue, cheeks, gums, and the floor and roof of the mouth. Sometimes, it may extend to the oropharynx, which is the part of the throat located at the back of the mouth.

It typically manifests as a persistent sore, patch, or lump that doesn't heal, and can be easily mistaken for a less serious issue in its initial phases.

If left unaddressed, oral cancer can spread to nearby structures, including lymph nodes and other parts of the head and neck, and in advanced cases, even distant organs. Despite its potential severity, oral cancer is highly treatable when diagnosed early.

Who is Most Affected by Oral Cancer?

While oral cancer predominantly affects individuals aged 60 and older, it can also occur in younger people. Men are statistically twice as likely to develop it compared to women. Among different racial groups, white men exhibit a higher incidence rate than Black men. Approximately 11 in 100,000 individuals receive an oral cancer diagnosis during their lifetime.

This type of cancer is particularly concerning due to its often painless and subtle early symptoms, which can lead to delays in diagnosis and treatment.

Oral Cancer Symptoms

Oral cancer often manifests as persistent changes in the mouth that do not resolve. These can include:

Visible Signs:

• White, red, or mixed patches (leukoplakia, erythroplakia, or erythroleukoplakia)
• Sores or ulcers that bleed easily and do not heal within two weeks
• Thickening or lumps in the cheek, gums, or tongue
• Crusty or rough areas on the lips or inside the mouth

Sensory and Functional Symptoms:

• Numbness or unexplained pain in the mouth or neck
• Difficulty or pain when chewing, swallowing, or speaking
• Unintentional weight loss
• Chronic earache or sore throat
• Persistent bad breath

These symptoms can mimic other conditions like infections or ulcers, but their persistence should be a cause for concern.

Oral Cancer: Self-Exam Tips for Early Detection

Performing a monthly self-exam can help identify unusual changes early:

• Examine your lips, gums, tongue, cheeks, and the roof and floor of your mouth.
• Look for patches, sores, lumps, or discolored areas.
• Feel your neck and jaw for any lumps or swelling.
• Use a bright light and a mirror to get a full view.

If you find anything unusual, it's important to consult a healthcare professional immediately.

How Oral Cancer Impacts the Body

Oral cancer can significantly impair a person’s ability to speak, chew, swallow, and even breathe, depending on the location and extent of the tumor. When it affects the oropharynx, it can lead to oropharyngeal cancer, which impacts the base of the tongue, soft palate, tonsils, and the back of the throat.

The oral cavity, where oral cancer typically begins, includes:

• Lips
• Gums
• Inner cheeks
• Front two-thirds of the tongue
• Floor of the mouth (under the tongue)
• Hard palate (roof of the mouth)
• Area near the wisdom teeth

Oral Cancer: Causes and Risk Factors

Oral cancer originates in squamous cells, which are thin, flat cells lining the inside of the mouth. When these cells undergo mutations, usually due to prolonged exposure to carcinogens, they start multiplying uncontrollably, forming tumors.

Major Risk Factors:

• Tobacco use: Smoking or chewing tobacco accounts for the majority of oral cancer cases.
• Excessive alcohol consumption: Alcohol irritates mucous membranes and increases cancer risk, particularly when combined with tobacco use.
• HPV infection: The human papillomavirus, especially strain HPV-16, has been linked to oropharyngeal cancers.
• Excessive sun exposure: Can cause lip cancer if lips are not protected with SPF.
• Poor oral hygiene and chronic irritation from broken teeth or ill-fitting dentures.
• Family history of cancer or genetic predispositions.

According to Healthline reports, approximately 25% of oral cancer cases occur in individuals without any of the above risk factors, highlighting the importance of regular oral screenings.

How Oral Cancer is Diagnosed

Diagnosis typically begins during routine dental or medical exams, with dentists often playing a crucial role in early detection.

Diagnostic methods include:

• Visual and physical examination
• Brush biopsy
• Incisional biopsy
• Laryngoscopy or pharyngoscopy

Once a lesion is confirmed as cancerous, additional tests are performed to determine the staging, which influences treatment options.

Stages of Oral Cancer

Oral cancer is staged using the TNM system:

• T (Tumor size):
  • T1: ≤2 cm
  • T2: >2 cm but ≤4 cm
  • T3: >4 cm
• N (Lymph nodes): Indicates if cancer has spread to lymph nodes.
• M (Metastasis): Shows whether the cancer has spread to other organs.

Staging helps doctors determine the most effective treatment and estimate the patient’s prognosis.

How to Prevent Oral Cancer

While not all cases can be prevented, the risk can be significantly reduced through:

• Avoiding tobacco and limiting alcohol use
• Using SPF lip balms and sun protection
• Eating a healthy diet rich in fruits and vegetables
• Getting the HPV vaccine
• Maintaining good oral hygiene
• Regular dental screenings every 1–3 years (depending on age)

Oral Cancer: Life After Treatment

Life after oral cancer treatment varies. Some patients experience minor changes, while others face long-term impacts on speaking, chewing, and appearance. Support from reconstructive surgery, physical therapy, speech therapy, and mental health counseling may be necessary. Ongoing check-ups are essential, as recurrence or secondary cancers are possible.